Qualified in Architecture (1975) and in Urbanism (1979), Caroline Mierop worked in these fields for 10 years. In 1985, she became director for the new-born Foundation for Architecture dedicated to modern and contemporary architecture. In 1989, the Foundation opened an art gallery.

From 1975 to 1996, alongside from her occupation at the Foundation, she taught architecture, mainly in Belgium but also in many Schools or Universities abroad.

In 1996, as project leader, she was in charge of the implementation of a thematic course on Art Nouveau. This project was organised around three main exhibitions with the partnership of public and private institutions, schools and universities, socio-cultural and professional organizations.

Back to Belgium at the end of 1999, she became cultural Consultant for Vivianne Reading, the European Commissioner for Education and Culture. She left this position in September 2003 when she was appointed Director of La Cambre, the national school for visual arts. In the context of this position, she is a member of the administration council of the Académie de recherche et d’enseignement supérieur en Communauté française de Belgique (ARES) and of many art and design schools in Europe. She is also a member of the scientific Council of research and studies for the French Cultural Ministry (2008-2013) and a member of the Artistic and Scientific Council of the Centre chorégraphique national de Franche-Comté (CCNFC) since 2010.

She has written many architecture books and articles. She has also been invited as speaker in many seminars, from 1985 to present-time.